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Altogether, these findings indicate that the antioxidant effects of metformin are achieved by Nrf2 nuclear translocation, increased downstream cytoplasmic HO-1 expression, and the subsequent activation of Nrf2 dependent signaling pathway

Flavanones are mostly found as glycosides, either rutinosides (-rhamnosyl- -16-glucosides) or neohesperidosides (-rhamnosyl- -12-glucosides) at C-7 of ring A (Reference Shakour, Fayek and Farag62,Reference Robards, Li and Antolovich63)

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DNA-repair defects and olaparib in metastatic prostate cancer